Nov 14, 2012 moreover, hyperbranched polymers were prepared from a 2type and b 3type monomers, 24, 25 and hyperbranched polymers with controlled degrees of branching were also prepared. Both hyperbranched polymers and ionic liquids break a variety of azeotropic systems. We aimed to assess imaging and therapeutic potential of hbp targeted to prostate cancer pca and loaded with a chemotherapeutic agent. Versatile synthesis of functional hyperbranched polymers. Chapter 5 summarises all the research presented in this thesis. Hyperbranched polymers hbps are a class of dendritic polymers that have been incorporated into many different electronic and biomedical applications. Dec 12, 2010 fluorescent hyperbranched polymers fhbps, which combine the versatile fluorescent property with unique characteristics of hyperbranched architecture, are desirable candidates for stimulus responsive materials. This book presents a comprehensive study on a new class of branched polymers, known as hyperbranched polymers hbps.
Nov 30, 2017 hyperbranched polymers are used in many applications due to their advantageous properties such as low intrinsic viscosity, low glass transition temperature, and large number of terminal groups. Hyperbranched polymers are used as polymeric additives in many linear commercial polymers as compatibilising agents, process and strength improvers. The resultant hyperbranched polymer with carboxylic acid terminal groups was endcapped with panisidine in order to avoid the aggregation effect in the. Their structure allows for conjugation with several specific functionalities. This thesis describes the development of a novel route for preparation of hyperbranched polymers. Hyperbranched polymers hbps have shown widespread academic and commercial success in the preparation of films and novel materials, and now are emerging into the biomedical research space as nanocarriers for use in drug delivery and diagnostics. Pdf in the present era, hyperbranched polymers hbps has been. Hyperbranched polymers download ebook pdf, epub, tuebl, mobi. In particular, the influence of uv intensity and reactive blend composition on structural transitions, such as gelation and vitrification, and on the dynamics of internal stress was considered.
Made in a very easy fashion divergent and convergent process 2. Future trends in the synthesis and application of hyperbranched polymers. Soluble hyperbranched polymers can be obtained by stopping the polymerization through precipitation or endcapping prior to the critical point of gelation, by the slow addition of monomer, or by using special catalysts and condensation agents. Voit and albena lederer leibniz institute of polymer research dresden, hohe strasse 6, 01069 dresden, germany received february 20, 2009 contents 1. Hyperbranched polymers are important soft nanomaterials but robust synthetic methods with which the polymer structures can be easily controlled have rarely been reported. The concentration of the hyperbranched polymers can be between about 0. Other approaches led to polymers with topologies similar to that of comb or star shaped polymer architectures. Ghent university, title versatile synthesis of functional hyperbranched polymers by combination of crp and thiolx chemistry, year 2015, subject chemistry year. Pdf chapter 2 hyperbranched polymers ahmad reza taheri. Polymers obtained from the statistical polymerization of a x b monomers by means of condensation or addition procedures are referred to as hyperbranched polymers.
Hyperbranched polymers with multiple alkyl bromide peripheral groups were synthesized by the copolymerization of styrene with ethylene glycol dimethacrylate 2. Hyperbranched polymers hbps are an emerging class of promising biocompatible agents for cancer imaging and therapy. Based on thermodynamic studies on the influence of hyperbranched polymers and ionic liquids on the vaporliquid and liquidliquid equilibrium of the azeotropic ethanolwater and thfwater systems. There is great commercial interest in hyperbranched polymers from manufacturers of polymer formulations, additives and coatings, polymer electronics and pharmaceuticals. More recently, the unique features of hbps have gained a considerable amount of attention for. Unlike welldefined dendrimers, hbps have linear units in structures except dendritic and terminal units, and the degree of branching db of them are usually less than 0. Written by leading scientists in academia and industry, this book provides for the first time a comprehensive. Hyperbranched polymers are highly branched macromolecules with threedimensional dentritic architecture. Hyperbranched polymer based coatings are with low voc, high solid content ecofriendly because they show lower viscosities at high molecular weights. The small thiolyne monomer was synthesized via 1ethyl33dimethylaminopropylcarbodiimide. Attractive features like highly branched topological structures, adequate spatial cavities, numerous terminal functional groups and convenient synthetic procedures distinguish them from.
Functional dendrimers, hyperbranched and star polymers k. Second, a novel hyperbranched polymer which combines ring open polymerisation and raft technique was developed. Jan 14, 2014 dendrimers vs hyperbranched polymers dendrimers hyperbranched polymers 1. Due to their unique physical and chemical properties and potential applications in various fields from drugdelivery to coatings, interest in hyperbranched polymers is growing rapidly, as confirmed by the increasing number of publications. Stimulus responsive fluorescent hyperbranched polymers and. Facing the global health crisis caused by drugresistant bacteria, antimicrobial peptides and their analogues offer exciting solutions to this widespread problem.
Without additionally introducing a fluorescent probe, novel nanoengineered peptidegrafted hyperbranched polymers npghps are constructed for their combined outstanding antimicrobial activity and sensitive bacterial detection in. Hyperbranched polymers show better thermal and mechanical properties than linear polymers. Nanoengineered peptidegrafted hyperbranched polymers for. In order to take advantage of this potential, the underlying phase behaviour must be known. A composition of polyolefin, ester additive, and hyperbranched polymer with improved tensile energytobreak value compared to polyolefins wihtout the hyperbranched polymer. Whereas dendrimers are highly uniform and monodisperse, hyperbranched polymers exhibit polydispersity and irregular branching as a consequence of their method of synthesis. May 04, 2011 how hyperbranched polymers compare with dendrimers as well as linear polymers. Interfacial and demulsifying behavior of novel fluorinated hyperbranched polymers. Influence of branching architecture on polymer properties pages.
How hyperbranched polymers compare with dendrimers as well as linear polymers. Phase diagrams for systems containing hyperbranched polymers. Targeted multimodal hyperbranched polymers for imaging and. From the thermodynamic point of view, the modelling of these phase diagrams is quite challenging, because the thermodynamic properties depend on the architecture of the. Hps can be facilely synthesized dendrimers and hyperbranched polymers. Chapter 4 demonstrates two routes to prepare novel coreshell polymers. Selfassembly of phospholipidanalogous hyperbranched polymers nanomicelles for drug delivery. Their globular and dendritic architectures endow them with unique structures and properties such as abundant functional groups, intramolecular cavities, low viscosity, and high solubility. Hyperbranched polymers wiley online books wiley online library. Hyperbranched polymers for biomedical applications. Albena lederer,walther burchard published on 20150820 by royal society of chemistry. Hps can be facilely synthesized via a onepot polymerization of traditional small molecular monomers or emerging. In 1833, jons jacob berzelius coined the term polymer from the greek word poly, meaning.
Nov 06, 20 hyperbranched polymers developed by our research group 18. Macromolecular transport hyperbranched polymers techlink. Hyperbranched polymer an overview sciencedirect topics. We propose a versatile approach to the production of hyperbranched polymers with high degrees of branching and low dispersity values d, involving slow monomer addition of a thiolyne monomer to multifunctional core molecules in the presence of photoinitiator and under uv irradiation. Based on a brief description of the synthesis and properties of hyperbranched polymers, a detailed overview of the research regarding the phase behavior of hyper branched polymers is given, followed by a discussion of new potential chemical engineering applications of hyperbranched. Hyperbranched and highly branched polymer architecturesssynthetic strategies and major characterization aspects brigitte i. Hyperbranched polymers developed by our research group 18.
Preparation of hyperbranched polymers by controlledliving. Hyperbranched polymers for biomedical applications abhijit. Versatile synthesis of functional hyperbranched polymers by combination of crp and thiolx. Hyperbranched polymers by albena lederer overdrive. Our strategy will be to use excess cui1 to control gelation, so called enhanced deactivation atrp. The obtained hyperbranched polyethers were hydrophobic so that they were insoluble in water. We chose the divergent initiator core method to synthesise three series of dendrimers with phloroglucinol, hydroquinone and naphthalene2,6diol as. The paper aims to give a brief historical background and to give a survey of hyperbranched polymers in. Thermoresponsive and reducible hyperbranched polymers. Hyperbranched polymers show an outstanding potential for applications ranging from chemistry over nanotechnology to pharmacy.
Assembly of hyperbranched polymers and its biomedical. Thus, whereas the synthesis of dendrimers requires a complex multistep process, hyperbranched polymers are synthesized via onestep reactions 1,2. More recently, the unique features of hbps have gained a considerable amount of attention for their potential use as drug delivery systems. Hyperbranched polymers as nanocarriers houston major. Hyperbranched polymers hbps as a polymer with a threedimensional and highly branched globular structure have emerged during the past twenty years 1,2,3,4. A novel hyperbranched polymer was synthesized using acrylamide am, acrylic acid aa, n vinyl2pyrrolidone nvp, and dendrite functional monomer as raw materials by redox initiation system in an aqueous medium.
Hyperbranched polymersilica nanocomposites which are very important in coating applications have been prepared and. Hyperbranched polymers are unique in that their properties are easily tailored by changing the nature of the end groups. Polydisperse mwmn and less than 100%degree of branching 3. The use of hyperbranched polymers as an alternative to perfect dendrimers as nanocarrier systems for drugs, dyes and other. Hyperbranched polymers is the first book to examine in detail the recent advances in hyperbranched polymers. A sketch of a hyperbranched polymer with n 21 nodes made of ab2 monomers is depicted in figure 2. Click download or read online button to get hyperbranched polymers book now.
Geared to novices and experts alike, hyperbranched polymers is a musthave resource for anyone working in polymer architectures, polymer engineering, and functional materials. A number of methods have been developed for the synthesis of dendrimers and related hyperbranched polymers. Inoue department of applied chemistry, faculty of engineering, ehime university, matsuyama 7908577, japan received 7 november 1999. Assembly of hyperbranched polymers and its biomedical applications yongfeng zhou school of chemistry and chemical engineering, state key laboratory of metal matrix composites, shanghai jiao tong university, 800 dongchuan road, shanghai 200240 p.
Cd molecules as monomers, their molecular inclusion capabilities for smaller molecular guests may be enhanced due to the combination of two. Based on the property of the solvents, polymers exhibit variable hydrodynamic radii. It covers all areas of research in polymer and biopolymer science including chemistry, physical chemistry, physics, material science. Aee active fhbps showing opposite performance to acq effect are used to. Since their selectivity, capacity, viscosity, and thermal stability can be customized, they appear superior to many conventional entrainers and extraction solvents.
History of hyperbranched polymers as shown in table 1, showing the development of hyperbranched polymers, highly branched arti. Dendrimers vs hyperbranched polymers dendrimers hyperbranched polymers 1. Mar 18, 2020 hyperbranched polymers hbps are a class of dendritic polymers that have been incorporated into many different electronic and biomedical applications. Hyperbranched polymers by albena lederer overdrive rakuten. First, the hyperbranched polydyb was used as a core to produce hyperbranched coreshell polymers. Chapter i provides a general introduction to the basic concepts of living. Synthesis and evaluation of a watersoluble hyperbranched. Thermoresponsive and reducible hyperbranched polymers synthesized by raft polymerisation by anna tochwin 1, alaa elbetany 1, hongyun tai 1, kai yu chan 1, chester blackburn 1 and wenxin wang 2. A muchneeded overview of the state of the art of hyperbranched polymers the last two decades have seen a surge of interest in hyperbranched polymers due to their ease of synthesis on a large scale and their promising applications in diverse fields, from medicine to nanotechnology. Growth click polymerization of ab2 monomers for the.
Hyperbranched polymers journal of macromolecular science. The molecular weight of hyperbranched polymers as well as dendrimers determined by sec using linear polymers such as polystyrene, polyethyleneoxide and. There is great commercial interest in hyperbranched polymers from manufacturers of polymer formulations, additives and coatings, polymer. Dendrimers are an important new class of macromolecule which have many potential applications from drug delivery to metal extraction. This site is like a library, use search box in the widget to get ebook that you want.
Developing drug delivery systems using hyperbranched polymers. Table 5 lists the a2 and b3 type monomers reported in the literature recent years. Ulsan national institute of science and technology. Pdf hyperbranched polymers for coating applications. The hbps can also incorporate a variety of anchors for adhesion in the coating and are engineered to deliver particular ionic species, bioreactive sites, or catalysts to the coating surface without leaching. Hyperbranched polymers hbp are modified with fluorinatedaliphatic chains that buoy the molecule to the surface of a coating.
Synthesis of structurally controlled hyperbranched polymers. It discusses in detail the synthesis strategies for these particular classes of polymers as well as biocompatible and biodegradable hbps, which are of increasing interest to polymer technologists due to their immense potential in biomedical applications. Hyperbranched polymers with high degrees of branching and. Hyperbranched polymers hps are highly branched threedimensional 3d macromolecules. Hyperbranched polymers for functional surfaces technology. The cyclodextrin cd molecule, a host for a variety of smaller molecular guests, and hyperbranched polymers both possess molecule cavities in their molecular architectures. Jun 21, 2015 hyperbranched polymers hbps, an important subclass of dendritic macromolecules, are highly branched, threedimensional globular nanopolymeric architectures. The hyperbranched polymer was characterized by infrared ir spectroscopy, 1 h nmr spectroscopy, c nmr spectroscopy, elemental analysis, and scanning electron microscope sem. Focusing on the structural characterization of hyperbranched polymers, the book summarizes the research in the field and makes a direct correlation between the chemical structure and global molecular properties. Separation of azeotropic mixtures using hyperbranched. Functional dendrimers, hyperbranched and star polymers.
Dendrimers and hyperbranched polymers are hot topics with broad and persistent interest for both academic and industrial researchers due to their unique threedimensional highlybranched topology, multifunctionality, special chemical and physical properties, and potential applications. Nanoengineered peptidegrafted hyperbranched polymers for killing of bacteria monitored in real time via intrinsic aggregationinduced emission jianliang zhao school of chemical sciences, university of chinese academy of sciences, beijing 49, china. Dendrimers and hyperbranched polymers home rsc publishing. Many research groups are now focusing their interest on dendritic macromolecules dendron greek treelike, highly branched i. Hyperbranched polymers by deyue yan overdrive rakuten. The high degree of branching for dendritic polymers has some consequences, e. For some areas, such as coating resins and tougheners in epoxyresins, hyperbranched polymers are foreseen to play an important role. Unlimited viewing of the articlechapter pdf and any associated supplements and figures.
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